Prognostic significance of the biomarker NT-proBNP in the surgical treatment of aortic stenosis (pilot study)

The objective was to study the relationship between preoperative blood levels of N-terminal segment B-type natriuretic peptide precursor (NT-proBNP) and ultrasound thermodilution indicators cardiac function before after on-pump surgery for aortic stenosis, as well evaluate prognostic significance biomarker in relation postoperative myocardial dysfunction. Materials methods . involved 27 patients aged 57.7±2.5 years who underwent valve replacement. NT-proBNP level determined surgery. invasive hemodynamics transesophageal echocardiography were analyzed at stages: I – anesthesia induction, II end Correlation analysis, logistic regression ROC analysis used. Results. 2002.0 [540.8–4001.5] pg/ml. At stage, correlated with mean pulmonary artery pressure (rho = 0.468; p 0.014), indices left ventricular –0.509; 0.007), end-diastolic end-systolic volumes 0.737–0.757; < 0.0001), ejection fraction –0.556; 0.004) area contraction –0.783; 0.0001). > 2000 pg/ml a predictor 50% (OR 1.0011, 95% CI 1.0002–1.0020, 0.028, AUC 0.799) , index 9 cm 2 /m 1.0007, 1.0001–1.0013, 0.027, 0.886), vasoactive-inotropic score 10 1.0006, 1.0001–1.0012, 0.032, 0.876), duration sympathomimetic therapy 24 h 1.0001, 1.0000–1.0003, 0.049, 0.889). Conclusions. increased 66.7% stenosis Moreover, directly correlates pressure, volumes, areas ventricle, it inversely stroke work index, fraction. decrease pathological fractions contraction, an increase intensive prolonged therapy. Myocardial dysfunctions most pronounced above